De zombiemodus in Call of Duty: Black Ops 2 is al vaker beschreven als 'de meest ambitieuze' en 'de grootste' of 'de meest vernieuwende tot nu toe'. In een interview met Digital Spy liet Treyarch zich uit over wat voor vernieuwingen ze door gaan brengen in de zombiemodus.

Zo zei John Rafacz hierover het volgende:

"The zombies mode is being developed in with the multiplayer engine, so you can imagine taking everything we can do in multiplayer and seeing how that's applied to the co-op mode.

The team has talked about things like four-vs-four and a range of new modes that we will get into down the road, but I can tell you without a doubt that it is easily the most ambitious and biggest zombies universe that we've ever attempted."